Blockbuster drugs - each of which generates more than a billion dollars a year in revenue - have revolutionized the industry since the early 1980s, when sales of Tagamet alone transformed a minor Philadelphia-based firm into the world's ninth-largest pharmaceutical company. In Blockbuster Drugs,
Jie Jack Li tells the fascinating stories behind the discovery and development of these highly lucrative medicines, while also exploring the tumult the industry now faces as the "patent cliff" nears.
Having spent most of his career in drug research and development, Li brings an insider's
eye to the narrative as he recounts the tales of discovery behind such drugs as Tagamet, Zantac, Claritin, Prilosec, Nexium, Serouquel, Plavix, and Ambien. As he discusses each breakthrough, Li also shows that scientific research is filled with human drama - serendipitous discoveries, sudden
insights, tense confrontations. For instance, the author tells of James Black, who persisted in the research that led to Tagamet - and that would ultimately win him a Nobel Prize - despite pressure from top executives to pursue "more profitable" work.
The book shows how research behind
Prilosec combined creativity, international cooperation, and luck - the turning point being a chance encounter of American and Swedish scientists at a conference in Uppsala. There are also tales of fabulous rewards - George Rieveschl, the chemist who invented Benadryl, made a fortune on royalties -
and of unjust desserts. Finally, Li shows that for the world's largest prescription drug manufacturers, recent years have been harrowing, as many popular drugs have come off patent in the U.S. market, meaning hundreds of billions of dollars in lost revenue.
Anyone who enjoys tales of
scientific discovery, or is curious about the history behind the prescriptions they take, or wants a revealing inside look at the pharmaceutical industry will find this book well worth reading.
1. Before the Age of Blockbuster Drugs
2. The Beginning of an Era - The First Blockbuster Drug Tagamet
3. More Blockbuster Drugs for Ulcer
4. Antihistamines as Allergy Medicines
5. Blood Thinners, From Heparin to Plavix
6. Conquest of Pain - Analgesics: from Morphine to
Lyrica
7. Lessons
Bibliography
Appendix
Index
There are no Instructor/Student Resources available at this time.
Jie Jack Li was a drug discovery chemist at Bristol-Myers Squibb Company. He is the author of Triumph of the Heart: The Story of Statins (Oxford, 2009), Modern Organic Synthesis in the Laboratory (Oxford, 2007), and Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use
(Oxford, 2006).
