Over 25 million people in the U.S. alone have benefited from statins - such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines - in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come
into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side
of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart
offers a compelling view of one of the most important drug discoveries of our time.
Prologue
1. Cholesterol
2. Genesis of Statins
3. Merck's Triumph
4. Discovery of Lipitor
5. Development of Lipitor
6. To Market, To Market
7. Baycol, Crestor, and Drugs beyond Statins
8. Reflections
Appendix
Trademarks of the Drugs
Bibliography and
Notes
Index
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Jie Jack Li currently works at Bristol-Myers Squibb Company. He was previously a medicinal chemist Parke-Davis Pharmaceuticals (which was bought in 2000 and closed in 2007 by Pfizer), the birth place of Lipitor. He is the author of Laughing Gas, Viagra, and Lipitor: The Human Stories behind
the Drugs We Use (OUP 2006). He lives in Connecticut.
Making Sense - Margot Northey and Joan McKibbin
