Eugene H. Cordes
Drug discovery in the pharmaceutical industry has important consequences for the health and wellbeing of people everywhere. However, the general public knows little about the paths through which basic research findings are translated into products that protect or restore human health: the route
from the laboratory bench to the bedside. In Hallelujah Moments, Eugene Cordes reveals how some of the most important and influential drugs have been brought into the practice of clinical medicine through the wit and determination of scientists in academia and industry. He shares his firsthand
knowledge of the drug-discovery world, having spent a long and distinguished career in both the academic and industrial settings.
These tales are "adventure stories," and they trace the route of important drugs like Januvia, Primaxin, Capoten, and Zocor from concept to the clinic. Cordes
shows us the dynamic and critical thinking needed to create a drug that meets important health needs. These are human stories of imagination, risk-taking, problem-solving, and perseverance. Written accessibly for a non-scientist audience, Hallelujah Moments provides insights into the fascinating
world of drug discovery like never before.
1. Seduced by drug discovery
2. The small molecules of life
3. Proteins: molecular wonders in three dimensions
4. Proteins perform multiple functions: enzymes, receptors, ion channels
5. Drug discovery and development: the road from an idea to promoting human health
6.
Finasteride: the Gary and Jerry show
7. Basic research, snake venoms, and ACE inhibitors: Ondetti, Cushman, and Patchett
8. Statins: protection against heart attacks and strokes
9. The perils of Primaxin
10. Avermectins: molecules of life battle parasites
11. Fludalanine: nice
try but no hallelujah
12. Diabetes Breakthrough: Januvia and Janumet
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Dr. Eugene Cordes has served as Vice President of Biochemistry and Molecular Biology in the Research Laboratories of Merck and Company and as President of Research and Development at Sterling Winthrop Pharmaceuticals Inc. In addition he has been a professor at Indiana University and the
University of Michigan. He is the author of The Tao of Chemistry and Life (OUP 2009) and several biochemistry textbooks.
