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Print Price: $148.50

Format:
Hardback
300 pp.
color & b/w illustrations, 7" x 10"

ISBN-13:
9781621823445

Publication date:
February 2020

Imprint: OUP US

The PTEN Family

Edited by Joanne Ngeow, Charis Eng and Vuk Stambolic

Series : Perspectives Series CSHL

PTEN is an important cellular enzyme that is frequently mutated in cancer. In normal cells, it downregulates signaling though the PI3-kinase pathway that controls cell proliferation. When PTEN is mutated, the PI3 pathway becomes overactive, which can contribute to cancer. This volume examines advances in our understanding of the functions of the PTEN protein, is regulation, and how loss of PTEN can promote the development and progression of different cancers.

Topics covered in this essential volume include:

- Structural Mechanisms of PTEN Regulation
- The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes
- PTEN Mouse Models of Cancer Development and Progression
- Autism Spectrum Disorder Associated with Germline Heterozygous PTEN Mutations
- PTEN Diagnostics: A Systems Pathology Approach

Readership : Libraries, Biologists working in subject areas, oncologists.

(preliminary)
Introduction:
1. PTEN discovery, basic genetics, Ramon Parsons
Section 1: Structure and Function
2. Structure: Structural Mechanisms of PTEN Regulation, Glenn R. Masson and Roger L. Williams
3. PTEN phosphatase activity, lipid, protein, Bangyan Stiles
4. Biophysics: Structure with emphasis on the dimerization of PTEN, Arne Gericke and Alonzo A. Ross
5. PTEN visualization, localization: Visualization of PTEN conformation changes and implications for disease, Mark Scott
6. The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes, Nicholas Hasle, Kenneth A. Matreyek, and Douglas M. Fowler
Section 2: Regulation
7. PTEN nuclear functions, Vuk Stambolic
8. The Complex Landscape of Post-Transcriptional PTEN Regulation, Erin Sellars, Martino Gabra, and Leonardo Salmena
9. PTEN mouse models of cancer development and progression, Pier Paolo Pandolfi
10. PTEN in Regulating Hematopoiesis and Leukemogenesis, Yilin Wu, Haichuan Zhu, and Hong Wu
Section 3: Signaling Pathways
11. PTEN, chromosomes, mitosis: Role of PTEN in mitosis and chromosome stability, Wen Shen
12. PTEN and Endocytosis, Matthew Lee and Lloyd Trotman
13. PTEN in Chromatin Remodeling, Jingyi Yang and Yuxin Yin
Section 4: PTEN and Human Disease
14. Human cancer - inherited and sporadic - overview and review of PHTS and PTEN role in sporadic cancers, Joanne Ngeow and Charis Eng
15. PTEN in the Stroma, Mike Ostrowski and Gustavo Leone
16. Intracellular localization and its functions of PTEN, Miho Iijima and Takashi Kato
17. Autism Spectrum Disorder Associated with Germline Heterozygous PTEN Mutations, Thomas W. Frazier
18. ASD-mouse models, Damon Page
19. PTEN in Autism and Neurodevelopmental Disorders, Sebastian Rademacher and Britta J. Eickholt
20. Metabolic Role of PTEN in Insulin Signaling and Resistance, Yu Zhe Li, Antonio di Cristofano, and Minna Woo
21. The Role of PTEN in Innate and Adaptive Immunity, Henry Taylor, Arian Laurence, and Holm H. Uhlig
22. PTEN diagnostics: A systems pathology approach, Deborah Marsh
23. Precise immunodetection of PTEN protein in human neoplasia, Rafael Pulido, Janire Mingo, Ayman Gaafar, Caroline E. Nunes-Xavier, Sandra Luna, Leire Torices, Javier C. Angulo, and José I. López
Index

There are no Instructor/Student Resources available at this time.

Joanne Ngeow is with the National Cancer Centre Singapore.

Charis Eng is with the Genomic Medicine Institute, Lerner Research Institute.

Vuk Stambolic is with the Princess Margaret Cancer Centre.

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