Molecular Biology

1. Genomes and the flow of biological information
2. Biological molecules
3. The chemical basis of life
4. Chromosome structure and function
5. The cell cycle
6. DNA replication
7. Chromosome segregation
8. Transcription
9. Regulation of transcription
10. RNA processing
11. Translation
12. Regulation of translation
13. Regulatory RNAs
14. Protein modification and targeting
15. Cellular responses to DNA damage
16. Repair of DNA double-strand breaks and homologous recombination
17. Mobile DNA
18. Genomics and genetic variation
19. Tools and techniques in molecular biology

Instructor Resources
- Figures from the book, available for download
- Journal club, including suggested research papers and discussion questions linked to topics featured in the book
- Answer key for end-of-chapter questions
Student Resources
- Links to video animations

Nancy L Craig joined the Department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine in 1991, where she is currently a Professor and a Howard Hughes Medical Institute Investigator, as well as the recipient of the Johns Hopkins University Alumni Association Excellence in Teaching Award.

Rachel Green is currently a Professor in the Department of Molecular Biology and Genetics at The Johns Hopkins University School of Medicine, an Investigator of the Howard Hughes Medical Institute, and a member of the National Academy of Sciences.

Carol Greider is currently the Daniel Nathans Professor and Director of the Department of Molecular Biology and Genetics, and a Bloomberg Distinguished Professor.

Gisela Storz is an NIH Distinguished Investigator. She is a member of the American Academy of Microbiology, American Academy of Arts and Sciences, and National Academy of Sciences, and received the American Society for Microbiology Eli Lilly Award.

Cynthia Wolberger is now Professor of Biophysics and Biophysical Chemistry and an Investigator of the Howard Hughes Medical Institute.

Special Features

• A focus on the underlying principles of molecular biology equips students with a conceptual framework on which to add further detail from the vast amount of scientific information available to us today.
• An emphasis on commonalities that exist between the three kingdoms of life - bacteria, archae, and eukaryotes-gives students an accurate depiction of our current understanding of the conserved nature of molecular biology and the differences that underpin biological diversity.
• An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book.
• Experimental Approach panels demonstrate the central importance of experimental evidence to furthering our understanding of molecular biology by describing valuable research.
• Online resources, for both instructors and students alike, enhance the educational value of the text.
• Video animations illustrate some of the central processes in molecular biology, including those that are particularly challenging to visualize.

• New and updated content on epigenetics, targets genome editing and pre-mRNA splicing.
• Cutting-edge scientific breakthroughs in CRISPR technology, including a description of newly defined steps in the molecular mechanisms underlying CRISPR-mediated adaptation in bacterial adaptive immunity.
• Enhanced coverage of DNA replication and regulatory RNAs.
• Seven new Experimental Approach panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology.