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Print Price: $104.99

Format:
Paperback
320 pp.
160 line illustrations, 189 mm x 246 mm

ISBN-13:
9780199569113

Copyright Year:
2011

Imprint: OUP UK


Introduction to Glycobiology

Third Edition

Maureen E. Taylor and Kurt Drickamer

Sugars are familiar as vital sources of energy. Yet the biological importance of the sugars extends well beyond their value as cellular fuels.

Introduction to Glycobiology reveals the true impact of the sugars on biological systems, explaining their function at the molecular, cellular, and organismal level. Employing a two-part structure, the book leads us through essential principles and concepts upon which the discipline is grounded, before exploring the diverse roles of sugars throughout biological systems, including development, cell signalling, and protein trafficking. It also emphasises the importance of glycobiology in disease, and explains how an understanding of the link between the two is enabling us to develop new therapeutic strategies.

Taking the student from the fundamental principles to the frontiers of the subject, and with a wealth of learning features to get the most out of their studies, Introduction to Glycobiology remains the ideal resource for students and teachers alike.

Online Resource Centre
For students:
* Updates - surveys of key developments in the field, provided on a six-monthly basis, to maintain currency
* Library of molecular structures to help students visualize structures and gain a proper appreciation of the link between structure and function
* Hyperlinked references to facilitate access to primary literature

For registered adopters of the book:
* Full colour figures, available for download individually or as PowerPoint slides with key explanatory points
* Answers to end of chapter questions
* Journal Clubs

Readership : Suitable for undergraduate and postgraduate biochemistry and biosciences students studying glycobiology. Also suitable for further reading on general biological sciences, biochemistry, cell biology, and immunology courses. The book is likely to be of wide interest to graduate students not necessarily taking a course in the subject as well as postdoctoral researchers and faculty members who want an introduction to this important interdisciplinary field.

Reviews

  • Review from previous edition: "This book is an absolute must for all lecturers and students alike of glycobiology ... Wholeheartedly recommended."

    --Microbiology Today, November 2006


  • "Dr Taylor and Professor Drickamer should be congratulated on writing a textbook that presents the enormous subject of glycobiology with energy and enthusiasm and doing so in a manner that should be accessible to their target audience."

    --Biochemist e-volution, April 2006

Part 1: Structures and biosynthesis of glycans
1. Concepts of glycobiology
2. N-Linked glycosylation
3. O-Linked glycosylation
4. Glycolipids and membrane protein glycosylation
5. Enzymology and cell biology of glycosylation
6. Glycomics: analysis of glycan structures
7. Conformations of oligosaccharides
Part 2: Glycans in biology
8. Effects of glycosylation on protein structure and function
9. Carbohydrate recognition in cell adhesion and signalling
10. Glycoprotein trafficking in cells and organisms
11. Glycobiology of plants, bacteria, and viruses
12. Glycobiology and development
13. Glycosylation and disease
14. The future of glycobiology

Online Resource Centre

Maureen Taylor is Senior Lecturer in Molecular Biosciences at Imperial College London and Fellow and Tutor in biochemistry at Exeter College, Oxford. Kurt Drickamer is Professor of Biochemistry in the Division of Molecular Biosciences at Imperial College London

Cell Signalling - Dr. John Hancock
Molecular Biology of Cancer - Lauren Pecorino
Making Sense - Margot Northey and Joan McKibbin

Special Features

  • The only text to make this important area of biochemistry accessible to an undergraduate audience.
  • Illustrates the biological importance of sugars with diverse examples, to stimulate and engage students throughout the biosciences.
  • Thought-provoking questions linked to the latest research encourage the student to explore the subject for themselves, and gain an appreciation of how current research continues to push forward our understanding of the subject.
  • The glycobiology of disease and the importance of sugars in the development of new therapeutic strategies are highlighted throughout.
  • Online Resource Centre features additional resources for students and lecturers to enhance the educational value of the text.
New to this Edition
  • Updated content to reflect the current state of the field: new chapter on cell biology of glycosylation, expanded coverage of congenital disorders, proteoglycans, influenza virus, muscular dystrophy, and cancer.
  • Marginal cross-references between the chemical first part and biological and biomedical second part of the book further emphasise the relevance of structure to function.
  • New and updated special topic boxes represent the current research and applications of glycobiology to disease and therapeutics.
  • Broadened treatment of analytical methods, including glycoarrays, provides an overview of the cutting edge techniques used to increase our understanding.
  • New Journal Clubs feature discussion questions based on research papers and linked to topics featured in the book, to guide the process of assimilating knowledge from the research literature.