1. What is organic chemistry?
2. Organic structures
3. Determining organic structures
4. Structure of molecules
5. Organic reactions
6. Nucleophilic addition to the carbonyl group
7. Delocalization and conjugation
8. Acidity, basicity, and pKa
9. Using
organometallic reagents to make C-C bonds
10. Nucleophilic substitution at the carbonyl group
11. Nucleophilic substitution at C=O with loss of carbonyl oxygen
12. Equilibria, rates and mechanisms
13. 1H NMR: Proton nuclear magnetic resonance
14. Stereochemistry
15.
Nucleophilic substitution at saturated carbon
16. Conformational analysis
17. Elimination reactions
18. Review of spectroscopic methods
19. Electrophilic addition to alkenes
20. Formation and reactions of enols and enolates
21. Electrophilic aromatic substitution
22.
Conjugate addition and nucleophilic aromatic substitution
23. Chemoselectivity and protecting groups
24. Regioselectivity
25. Alkylation of enolates
26. Reactions of enolates with carbonyl compounds: the aldol and Claisen reactions
27. Sulfur, silicon and phosphorus in organic
chemistry
28. Retrosynthetic analysis
29. Aromatic heterocycles 1: structures and reactions
30. Aromatic heterocycles 2: synthesis
31. Saturated heterocycles and stereoelectronics
32. Stereoselectivity in cyclic molecules
33. Diastereoselectivity
34. Pericyclic reactions
1: cycloadditions
35. Pericyclic reactions 2: sigmatropic and electrocyclic reactions
36. Participation, rearrangement and fragmentation
37. Radical reactions
38. Synthesis and reactions of carbenes
39. Determining reaction mechanisms
40. Organometallic chemistry
41.
Asymmetric synthesis
42. Organic chemistry of life
43. Organic chemistry today
Online Resource Centre http://www.oxfordtextbooks.co.uk/orc/clayden2e
Student Resources:
Sapling Learning Online Homework System - features automatic homework grading, tutorial instruction, diagnostic feedback, algorithmic
questions, and dedicated user support from chemists
End-of-Chapter Questions - feature a range of problems to help students assess whether they have understood the material covered in each chapter
3D Organic Animations - links are provided throughout the book to ChemTube3D, which contains
interactive animations and structures, along with supporting information, to allow students to appreciate the material in three dimensions
Instructor Resources:
PowerPoint Slides - feature figures from the book in electronic format for use in lectures and as handouts
E-Book ISBN
9780191645587
Jonathan Clayden is a Professor of Organic Chemistry at the University of Manchester, where he and his research group work on the construction of molecules with defined shapes - in particular those where control of conformation and limitation of flexibility is important. Jonathan was awarded a
BA (Natural Sciences) from Churchill College, Cambridge before completing his PhD with Stuart Warren, also at the University of Cambridge. He has been at the University of Manchester since 1994. Nick Greeves is the Director of Teaching and Learning in the Department of Chemistry at the University of
Liverpool. Nick is a Cambridge graduate, obtaining his PhD there in 1986 for work on the stereoselective Horner-Wittig reaction with Stuart Warren. He then held a Harkness Fellowship at the University of Wisconsin-Madison and at Stanford University, California, and a Research Fellowship at Cambridge
University before joining Liverpool in 1989 where he is currently a Senior Lecturer. Stuart Warren is a former lecturer in the Department of Chemistry at the University of Cambridge and Fellow of Churchill College, Cambridge. A graduate of Trinity College, Cambridge, Stuart completed his PhD at
Cambridge with Malcolm Clark before carrying out post-doctoral research at Harvard University. He became a teaching fellow at Churchill College in 1971, and remained a lecturer and researcher at Cambridge until his retirement in 2006.
Making Sense - Margot Northey and Joan McKibbin
