Graham L. Patrick
The average person in the UK will take more than 14,000 pills over the course of their life, yet few people consider the long road of development that has made that drug work without being toxic. An Introduction to Medicinal Chemistry presents the field in an engaging style that is very
accessible to students.
Medicinal chemistry is a fast-moving field whose continuous new developments have far-reaching implications for world health. As such, this text presents a complete course in medicinal chemistry, from first principles of drug action, to design and development, to
specific drugs from HIV inhibitors to painkillers.
The book builds on the history of drug development, but does not assume much background knowledge. The focus is on building upon the understandings of the molecular function of drugs, and from there, taking a broad overview of the topical
issues and most frequently used techniques.
An Introduction to Medicinal Chemistry remains a leading text for the growing number of medicinal chemistry courses internationally, especially as modules in medical chemistry become a more popular option on chemistry courses. With enhanced
attention to the pedagogical details such as key points and boxes, as well as having specific case studies highlighted in distinct sections, Patrick's new edition enables a full understanding of the subject and a clear idea of where the field is heading.
Online Resource Centre
The Online Resource Centre features:
For registered adoptors of the book:
· Answers to end-of-chapter questions
· Figures from the book
· Power Point slides
· Test Bank questions
For students:
· Hyperlinked bibliography
· Six-monthly
updates to text
· 3D Rotatable structures
1. Drugs and drug targets: an overview
PART A: Drug targets: Structure and Function
2. Protein structure and function
3. Enzymes: structure and function
4. Receptors: structure and function
5. Receptors and signal transduction
6. Nucleic acids - structure and
function
PART B: Pharmacodynamics and pharmacokinetics
7. Enzymes as drug targets
8. Receptors as drug targets
9. Nucleic acids as drug targets
10. Other drug targets
11. Pharmacokinetics and related topics
Case study 1: Statins
PART C: Drug
discovery, design, and development
12. Drug discovery: finding a lead
13. Drug design: optimizing target interactions
14. Drug design: optimizing access to the target
15. Drug development
Case study 2: The design of ACE inhibitors
Case study 3: Artemisinin
and related antimalarial drugs
Case study 4: The design of oxamniquine
PART D: Tools of the trade
16. Combinatorial synthesis
17. Computers in medicinal chemistry
18. Quantitative structure-activity relationships (QSAR)
Case study 5: De novo design
of a thymidylate synthase inhibitor
Case study 6: Design of a serotonin antagonist
PART E: Selected topics in medicinal chemistry
19. Antibacterial agents
20. Antiviral agents
21. Anticancer agents
22. The peripheral nervous system: cholinergics,
anticholinergics, and anticholinesterases
23. The andrenergic nervous system
24. The opium analgesics
25. Anti-ulcer agents
The Online Resource Centre features:
For registered adoptors of the book:
Answers to end-of-chapter questions
Figures from the book
Power Point slides
Test Bank questions
For students:
Hyperlinked bibliography
Six-monthly updates to text
3D
Rotatable structures
Graham Patrick is a lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland, Paisley. He is the author of four other undergraduate textbooks covering medicinal chemistry and organic chemistry.
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