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Price: $159.50

Hardback 416 pp.
60 illustrations, 7.2" x 10"



Publication date:
March 2010

Imprint: OUP US

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Peripheral Neuropathies in Clinical Practice

Dr. Steven Herskovitz, Dr. Stephen Scelsa and Dr. Herbert Schaumburg

Series : CONTEMP NEURO, 76

The last 2 decades have seen enormous strides in our understanding of the biological, genetic and clinical basis of the peripheral nerve disorders. This remains a difficult area for most practitioners. This text combines a thorough review of the neurologic literature with clinical experience in presenting a comprehensive yet concise and readable approach to the understanding, evaluation and management of these disorders. All practitioners seeing these patients, as well as all trainees in Neurology and related fields, should find this a useful, approachable initial resource.

Readership : Suitable for all neurology residents. Alos all General Neurology practitioners. PM& R practitioners and residents, general medicine, medical students, academic EMG labs/neuromuscular divisions, clinical toxicologists, and neuropathologists

1. Basic Concepts and Glossary of Common Clinical Terms
Definition of the Peripheral Nervous System (PNS)
Relationships Fundamental to an Understanding of Disease of Peripheral Nerve Fibers
Neuron Cell Body and Axon
Axon, Schwann Cell and Myelin
Axon and End Organ
Wallerian Degeneration and Axon Regeneration
Glossary of Common Clinical Terms
2. Anatomic Classification of Peripheral Nervous System Disorders
Symmetric Generalized Neuropathies (Polyneuropathies)
Distal Axonal Degeneration
Segmental (Non-Uniform) Myelinopathy
Diffuse (Uniform) Myelinopathy
Neuronopathy (Ganglionopathy)
Focal (Mononeuropathy) and Multifocal (Multiple Mononeuropathy) Neuropathies
Physical Injuries
3. Evaluation and Management of the Patient with Peripheral Neuropathy
General Principles and the Algorithmic Approach
Chronic Idiopathic Axonal Polyneuropathy / Small Fiber Neuropathy
Treatment of Neuropathic Pain
Differential Diagnoses and Work-ups for the Varied Neuropathy Phenotypes (Tables)
Sensorimotor Polyneuropathies - Axonal
Sensorimotor Polyneuropathies - Demeyelinating or Mixed
Sensory, Small Fiber, Painful Polyneuropathies
Sensory, Large Fiber, Ataxic Polyneuropathies
Motor Neuropathies
Autonomic Neuropathies
Mononeuropathy Multiplex
Polyneuropathy and Optic Neuropathy
Facial Neuropathy
Trigeminal Sensory Neuropathy
Unusual Neuropathy Patterns
4. Electrodiagnostic, Imaging, Nerve and Skin Biopsy Investigations in Peripheral Nerve Disease
Electromyography and Nerve Conduction Studies
Sensory Nerve Conduction Studies
Motor Nerve Conduction Studies
Late Responses
Blink Reflex Studies
Needle Electromyography
Studies of Autonomic Function
Quantitiative Sudomotor Axon Reflex Test
Thermoregulatory Sweat Test
Heart Rate Response to Deep Breathing
Valsalva Maneuver
Quantitative Sensory Testing
Developing Electrophysiologic and Imaging Techniques
Motor Unit Number Estimation
Electrical Impedence Myography
High-Resolution Sonography of Peripheral Nerve
Magnetic Resonance Neurography
Muscle MRI
Positron Emission Tomography
Nerve Biopsy
Skin Biopsy
5. Case Presentations Illustrating the Diagnostic Method
Case 1: Painful small fiber neuropathy and dysautonomia
Case 2: Insidious onset of distal weakness in an adult with deformed feet
Case 3: Lower limb paresthesias in a middle-aged adult with diabetes
Case 4: A middle-aged woman with muscle twitching and episodic numbness
Case 5: Six days of cranial neuropathies and hyporeflexia
Case 6: A two-month onset of sensory neuropathy in a woman with ovarian carcinoma
Case 7: A 47-year-old man with 10 years of progressive bilateral hand weakness
Case 8: Chronic sensory loss and unsteady gait in a 59-year-old woman
Case 9: An elderly man with acral paresthesias and gait unsteadiness
Case 10: Foot drop in an 81-year-old woman
Case 11: A middle-aged man with multifocal pain, sensory loss and weakness
Case 12: Five-day onset of diffuse weakness
6. Acute Immune-mediated Neuropathies
Demyelinating Immune-mediated Neuropathies
Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP) and Fisher Syndrome (FS)
Axonal Immune-mediated Neuropathies
Acute Motor Axonal Neuropathy (AMAN) and Acute Motor and Sensory
Axonal Neuropathy (AMSAN)
Sensory (Idiopathic, Sjogren Syndrome, Paraneoplastic) and Motor (Paraneoplastic) Neuronopathies and Autoimmune Autonomic Ganglionopathy
7. Chronic Immune-mediated Neuropathies
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
CIDP Variants:
Multifocal Motor Neuropathy with Conduction Block (MMN)
Lewis-Sumner Syndrome (LSS)/Multifocal Acquired Demyelinating Sensory and Motor Neuropathy (MADSAM)
Distal Acquired Demyelinating Symmetric Neuropathy (DADS)
CIDP with CNS Features
Chronic Immune Sensory Polyradiculopathy (CISP)
Chronic Sensory Demyelinating Polyneuropathy
8. Neuropathies Associated with Monoclonal Gammopathies and Cancer
Multiple Myeloma
Osteosclerotic Myeloma
Primary Systemic Amyloidosis (AL Amyloidosis)
Waldenstrom Macroglobulinemia
Monoclonal Gammopathy of Undetermined Significance
9. Infectious and Granulomatous Neuropathies
Herpes Zoster/Herpes Simplex
Lyme Disease
Hepatitis C/Cryoglobulinemia
10. Diabetic and Other Endocrine Neuropathies
Diabetic Neuropathies
Distal Symmetric Sensorimotor/Autonomic Polyneuropathy
Proximal Multifocal Neuropathies
Lumbosacral Radiculoplexus Neuropathy
Thoracolumbar "Truncal" Radiculoneuropathy
Focal Limb Neuropathies (Entrapment Sites)
Isolated Cranial Neuropathies
Acute Painful Neuropathy ("Diabetic Neuropathic Cachexia")
Diabetic Motor-predominant Neuropathies
Treatment-induced Neuropathy ("Insulin Neuritis")
Hyperglycemic Neuropathy
Acromegalic Neuropathy
Hypothyroid Neuropathy
11. Neuropathies Associated with Vitamin Deficiencies and Malabsorption
Vitamin B12 (Cobalamin) Deficiency
Vitamin B1 (Thiamine) Deficiency
Celiac Disease
Vitamin E (?-tocopherol) Deficiency
Copper Deficiency
Other: Cuban Epidemic Optic and Peripheral Neuropathy; Deficiencies: Riboflavin (B2), Pyridoxine (B6), Folate, Zinc; Bariatric Surgery
12. Vascular/Ischemic Neuropathies
Vasculitic Neuropathies
Neuropathies Associated with Peripheral Arterial Occlusive Disease
Neuropathies Associated with Compartment Syndromes
13. Neuropathies Associated with Organ Failure
Pulmonary Failure
Hepatic Failure
Renal Failure
Uremic Polyneuropathy
Ischemic Monomelic Neuropathy
Organ Transplantation
Critical Illness Polyneuropathy
Differential Diagnosis
14. The Hereditary Neuropathies
Hereditary Motor and Sensory Neuropathies
Charcot-Marie Tooth Disease, Type 1
Hereditary Neuropathy with Liability to Pressure Palsy
Charcot-Marie Tooth Disease, Type 2
Dejerine-Sottas Disease/Congenital Hypomyelinating Neuropathy
Charcot-Marie Tooth Disease, Type 4
Charcot-Marie Tooth, Type X
Charcot-Marie-Tooth Disease-Dominant Intermediate
Hereditary Sensory and Autonomic Neuropathies
Distal hereditary Motor Neuropathy/Neuronopathy
Hereditary Ataxia with Neuropathy
Autosomal Dominant
Autosomal Recessive
Hereditary Spastic Paraplegia with Neuropathy
Hereditary Brachial Plexus Neuropathy/Hereditary Neuralgic Amyotrophy
Hereditary Peripheral Nerve Channelopathies
Sodium Channelopathies
Potassium Channelopathies
15. Hereditary Metabolic/Multisystem Disorders with Neuropathy
Familial Amyloid Polyneuropathies
Disorders of Lipid Metabolism
Lysosomal Disorders
Fabry Disease
Metachromatic Leukodystrophy
Krabbe Disease
Peroxisomal Disorders
Refsum Disease
Lipoprotein Deficiencies
Tangier Disease
Familial Hypobetalipoproteinemia
Cerebrotendinous Xanthomatosis
Disorders of Heme Metabolism - Porphyria
Disorders of Defective DNA Repair
Mitochondrial Disorders
Neuroacanthocytosis Syndromes
McLeod Syndrome
Neurofibromatous Neuropathy
Glycogen Storage Diseases
Adult Polyglucosan Body Disease
16. The Toxic Neuropathies: Principles of General and Peripheral Neurotoxicology; Pharmaceutical Agents
Principles of General Neurotoxicology
Principles of Peripheral Neurotoxicology
Peripheral Neurotoxicity Associated with Pharmaceutical Agents
17. The Toxic Neuropathies: Industrial, Occupational and Environmental Agents
Peripheral Neurotoxicity Associated with Industrial, Occupational and Environmental Agents
18. Focal neuropathies: Nerve injuries, Entrapments and Other Mononeuropathies
Nerve Injuries
Anatomy and Pathophysiology of Nerve Injuries
Clinical Classification or Nerve Injuries
Electrodiagnostic Features of Nerve Injuries
Nerve Regeneration and Repair
Focal Neuropathies: The Upper Extremity
Median Nerve
Ulnar Nerve
Radial Nerve
Other Upper Extremity Mononeuropathies
Focal Neuropathies: The Lower Extremity
Sciatic nerve
Peroneal Nerve
Tibial Nerve
Femoral Nerve
Lateral Femoral Cutaneous Nerve
Other Lower Extremity Mononeuropathies
Focal Neuropathies: Cranial Neuropathies
Idiopathic Facial Nerve Paralysis (Bell's palsy)
19. Plexopathies
Brachial Plexopathy
Thoracic Outlet Syndrome
Neoplastic Brachial Plexopathy
Radiation-induced Brachial Plexopathy
Immune Brachial Plexus Neuropathy (Neuralgic Amyotrophy)
Lumbosacral Plexopathy
Trauma and Ischemia
Retroperitoneal Hemorrhage
Neoplastic Lumbosacral Plexopathy
Radiation-induced Lumbosacral Plexopathy
Non-diabetic Lumbosacral Radiculoplexus Neuropathy
20. Disorders of Peripheral Nerve Hyperexcitability
Facial Myokymia
Localized or Focal Myokymia
Hemifacial Spasm
Hemimasticatory Spasm
Hypothenar Dimpling

There are no Instructor/Student Resources available at this time.

Steven Herskovitz is Professor of Clinical Neurology and Director of the Neuromuscular Division and EMG Lab, Montefiore Medical Center/Albert Einstein College of Medicine. Stephen Scelsa is Associate Professor of Clinical Neurology, Montefiore Medical Center/Albert Einstein College of Medicine. Herbert Schaumburg is Professor of Neurology and Pathology, Montefiore Medical Center/Albert Einstein College of Medicine. The authors are recognized neuromuscular experts, having published extensively on various clinical and basic science aspects of neuropathies, electrodiagnostic studies, neurotoxicology and ALS.

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Special Features

  • Contains diagnostic algorithms and case studies to assist neurologists and neurology residents who aim to better understand, evaluate, and manage peripheral nerve disorders.
  • The book is comprehensive and concise which makes it a good initial resource on the subject.