P. David Josephy and Bengt Mannervik
Part One: Toxicity at the Cellular Level
1. Toxicology of Oxygen
2. Covalent Binding of Xenobiotics to DNA and Protein
3. DNA Repair
4. Chemical Mutagenesis
5. Oncogenes, Tumor Suppressor Genes, and Mutations in Cancer Cells
6. Toxicity, Survival, and Target Theory
Part Two: Enzymology of Biotransformation
7. Cytochrome P450: Chemical and Biochemical Aspects
8. P450: Biological Aspects, Regulation, Genetics
9. Biochemistry of Glutathione
10. Glutathione Transferases
11. Glutathione and Glutathione Transferases: Toxicological and
Pharmacological Aspects
12. Glucuronic Acid Conjugation
13. Arylamine N-Acetyltransferase
14. Sulfotransferase
Part Three: Molecular Principles Applied to Specific Toxicants
15. Alkylating Agents and "Mustards"
16. Oxidative Stress in the Erythrocyte: Congenital and Xenobiotic-Induced Methemoglobinemia
17. Aromatic Amines and Related Toxic Compounds
18. Polycyclic Aromatic
Hydrocarbon Carcinogens
19. Acetaminophen
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P. David Josephy is Professor of Molecular and Cellular Biology at the University of Guelph. Bengt Mannervik is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.
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