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Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.

Print Price: $181.50

Format:
Hardback
608 pp.
355 halftones & line illus., 257 mm x 185 mm

ISBN-13:
9780195176209

Publication date:
February 2006

Imprint: OUP US


Molecular Toxicology

Second Edition

P. David Josephy and Bengt Mannervik

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Part One: Toxicity at the Cellular Level
1. Toxicology of Oxygen
2. Covalent Binding of Xenobiotics to DNA and Protein
3. DNA Repair
4. Chemical Mutagenesis
5. Oncogenes, Tumor Suppressor Genes, and Mutations in Cancer Cells
6. Toxicity, Survival, and Target Theory

Part Two: Enzymology of Biotransformation
7. Cytochrome P450: Chemical and Biochemical Aspects
8. P450: Biological Aspects, Regulation, Genetics
9. Biochemistry of Glutathione
10. Glutathione Transferases
11. Glutathione and Glutathione Transferases: Toxicological and Pharmacological Aspects
12. Glucuronic Acid Conjugation
13. Arylamine N-Acetyltransferase
14. Sulfotransferase

Part Three: Molecular Principles Applied to Specific Toxicants
15. Alkylating Agents and "Mustards"
16. Oxidative Stress in the Erythrocyte: Congenital and Xenobiotic-Induced Methemoglobinemia
17. Aromatic Amines and Related Toxic Compounds
18. Polycyclic Aromatic Hydrocarbon Carcinogens
19. Acetaminophen

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P. David Josephy is Professor of Molecular and Cellular Biology at the University of Guelph. Bengt Mannervik is the Karin and Herbert Jacobsson Professor of Biochemistry at Uppsala University, Sweden.

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