Edited by Charles F. Sing and Craig L. Hanis
The objective of this book is to review the impact of genetic variation on risk of human disease at the different major levels of organization: cells, individuals, families, and populations. The volume begins with a discussion of sources and rates of mutation which ultimately give rise to the
vast amount of extant genetic variation. This is followed by presentations of current understanding of how genetic variation is maintained within and among populations. The volume ends with discussions of the implications of such variation for understanding the evolution of our species. This
collection gives an unusually broad treatment of the subject, with chapters from some of the leading workers in the field. James Neel's chapter on human consanguinity effects and M. Otake's on the genetic effects of radiation associated with the dropping of the Hiroshima and Nagasaki atomic bombs
should be singled out for special emphasis. As an up-to-date overview of ongoing research, this work will be of interest to a wide range of workers in the fields of human population genetics, evolution, and epidemiology.
1. K.M. Weiss: Medieval mappaemundi and the Conceptual Map of Genetics: Changing Views of Cancer Biology and Other Thoughts
2. A. Chakravarti: Impact of Genetic, Somatic, and Epigenetic Variation on Phenotype
3. R.E. Ferrell: Impact of Genetic Variation in Individuals--Clonal Phenotypes
Other Than Cancer
4. J.V. Neel: Human Consanguinity Effects Revisited: Why is Measurable Impact of Inbreeding So Small?
5. M. Otake: Genetic Risks from Exposure to the Atomic Bombs: Hiroshima and Nagasaki
6. E. Boerwinke and D.M. Hallman: Genotype by Environment Interaction--It's a Fact
of Life
7. S.P. Daiger and S.H. Blanton: Problems and Pitfalls in Linkage Mapping of Human Genetic Diseases: Illustrations from Autosomal Dominant Retinitis Pigmentosa (ADRP)
8. J.W. MacCluer: Applications of Pedigree Analysis to Animal Models for Complex Diseases
9. C.F. Sing and S.
Reilly: Genetics of Common Diseases that Aggregate, but do not Segregate, in Families
10. A.G. Knudson, Jr.: Pathodemes: Heredity, Environment, and Populations of Disease Susceptibility
11. C.L. Hanis: Genetic Inferences for Epidemiologic Investigations
12. R. Chakroborty: Generalized
Occupancy Problem and Its Applications in Population Genetics
13. B.R. Levin: The Maintenance of Genetic Variation in Bacterial Populations
14. P.E. Smouse: Some Theoretical Predictions for Electrophoretic Polymorphisms Maintained by Balancing Selection
15. E.J.E. Szathmary: Application
of Our Understanding of Genetic Variation in Native North America
16. Genetic Variation and Evolution of Human Populations, M. Nei, G. Livshits, and T. Ota
17. W.-H. Li, W. Xiong, S.-W. Liu, and L. Chan: Nucleotide Diversity in Man and Evidence for the Absence of a Severe Bottleneck during
Human Evolution
18. J.N. Spuhler: Population Genetics and Evolution in the Genus Homo in the Last Two Million Years
There are no Instructor/Student Resources available at this time.
Charles F. Sing is at University of Michigan Medical School. Craig L. Hanis is at University of Texas Health Science Center at Houston.
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